Citra-Lock™ Anti-Biofilm

In a randomized trial Citra-Lock™ reduces the formation of microbial biofilm in hemodialysis catheters and culture-positive colonization. It is likely that this is the explanation for the observed prevention of catheter-related infections byCitra-Lock locking.

Bosma J.W.1, Weijmer M.C.1, Peerbooms P.G.H.2, Siegert C.E.H.1
1 Department of Nephrology and Dialysis, 2 Department of Medical Microbiology and Infection Control, Sint Lucas
Andreas Hospital, Amsterdam - The Netherlands; 2009 Vascular Acces.

Mode of action:

Citrate binds to calcium:

It is known that the construction of the biofilm is dependent on Calcium and
Magnesium. Citra-Lock^TM is a strong chelator of both Mg²⁺ and Ca²⁺ 
leading to a decreased biofilm formation in catheters filled with Citra-Lock^TM
and in this way preventing the catheter of related infections.