Citra-Lock™ Anti-coagulant

Citra-lock™ causes anticoagulation by chelation of ionised calcium  in the extracorpereal circuit into a soluble complex. Because calcium is an integralion involved in the clotting cascade, local removal by Citra-Lock™ prevents  the activation of clotting factors, factor X, and prothrombin, and the ultimate formation of fibrin. Systematic anticoalgulation does not occur.

This figure  shows a 4 month period with a zero use of Urokinase (thrombolytic agent), proving that tri sodium  citrate 46,7% (Citra-Lock™) prevents the catheter related thrombosis ¹.

1. Ash SR (2000) Concentrated Sodium Citrate (23%) for Catheter Lock. Haemodialysis International 4:22-31