Citra-Lock™ 4%
Citra-Lock™ 4% (trisodium-citrate) The safe and effective way to lock every catheter
The EFFECTIVE way lock every catheter
Citra-Lock™ is effective
in maintaining catheter patency.
Trisodium citrate 4% (TSC) works
as an anti-coagulant and does not apear
to have any increased incidence of infection.
Clinical advantage of Citra-Lock™ 4% (compared with heparine):
- reduction of tPA use
- better outcomes over catheter exchange
- reduces biofilm
- reduction of hospitalisation
- cost efficient

The catheter exchange rates
were greater for catheters locked
with heparin ( 2,98/1000 CVC days)
compared with trisodium citrate 4%
(1,65/1000 CVC days)
The SAFE way to lock every catheter
Citra-Lock™ 4% is recommended by the European Renal Best Practice Guidelines (ERBP) and the American Society of Diagnostic and Interventional Nephrology (ASDIN).
Citrate Locks have been extensively studied and offers the best benefit/risk ratio.
Clinical advantage of Citra-Lock™ 4% (compared with heparine):
- safe
- avoids heparin-associated bleeding
- improves reliability of INR assyas (prothrombin time - time/international normalised ratio)
- safe for heparin induced thrombocytopenia (HIT patients)
- no side effects
Go to the brochures to Download the new Citra-Lock™ 4% brochure
Citra-Lock™ (Trisodium citrate 4%)
1. MacRae J et al, Citrate 4% versus Heparin and the Reduction of Thrombosis Clin J Am Soc Nephrol 3:369-374, 2008
2. Lok CE et al, Trisodium citrate 4%-an alternatieve to heparin capping of haemodialysis catheters. Nephrol Dial Transplant 22, 477-483, 2005
3. Shanks RM, Catheter Lock Solutions Influence Staphylococcal Biofilm Formation on Abiotic Surfaces. Nephrol Dial Transplant 21, 2247-2255, 2006
4. Grudzinski L et al, Sodium citrate 4% locking solution for central venous dialysis catheters -an effective, more cost-efficient alternative to heparin. Nephrol Dial Transplant 22: 471-476, 2007
5. Meeus G et al, A prospective, randomized, double-blind crossover study on the use of 5% citrate-lock vs 10% citrate lock. Blood Purif 23, 101-105, 2005
6. Vanholder et al, Diagnosis, prevention and treatment of haemodialysis catheter-related blood stream infections (CRBSI), a position statement of European Renal Best Practice (ERBP). NDTplus June 2010
7. Moran JE and Ash SE, Locking Solutions for Hemodialysis Catheters; Heparin and Citrate. A Position Paper by ASDIN. Seminars in Dialysis 21,1-3 , 2008
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