Citra-Lock™ 4% (trisodium-citrate) The safe and effective way to lock every catheter

The EFFECTIVE way lock every catheter

Citra-Lock™ is effective
in maintaining catheter patency.

Trisodium citrate 4% (TSC) works
as an anti-coagulant and does not apear
to have any increased incidence of infection.

Clinical advantage of Citra-Lock™ 4% (compared with heparine):

• reduction of tPA use
• better outcomes over catheter exchange
• reduces biofilm
• reduction of hospitalisation
• cost efficient

The catheter exchange rates 
were greater for catheters locked
with heparin ( 2,98/1000 CVC days)
compared with trisodium citrate 4%
(1,65/1000 CVC days) 

The SAFE way to lock every catheter 

Citra-Lock™ 4% is recommended by the European Renal Best Practice Guidelines (ERBP) and the American Society of Diagnostic and Interventional Nephrology (ASDIN).

Citrate Locks have been extensively studied and offers the best benefit/risk ratio. 

Clinical advantage of Citra-Lock™ 4% (compared with heparine):

• safe
• avoids heparin-associated bleeding
• improves reliability of INR assyas (prothrombin time - time/international normalised ratio)
• safe for heparin induced thrombocytopenia (HIT patients)
• no side effects 

Go to the brochures to Download the new Citra-Lock™ 4% brochure

Citra-Lock™ (Trisodium citrate 4%)

1.  MacRae J et al, Citrate 4% versus Heparin and the Reduction of Thrombosis  Clin J Am Soc Nephrol 3:369-374, 2008
2.   Lok CE et al, Trisodium citrate 4%-an alternatieve to heparin capping of haemodialysis catheters.  Nephrol Dial Transplant 22, 477-483, 2005
3.   Shanks RM, Catheter Lock Solutions Influence Staphylococcal Biofilm Formation on Abiotic Surfaces. Nephrol Dial Transplant 21, 2247-2255, 2006
4.   Grudzinski L et al, Sodium citrate 4% locking solution for central venous dialysis catheters -an effective, more cost-efficient alternative to heparin. Nephrol Dial Transplant 22: 471-476, 2007
5.   Meeus G et al, A prospective, randomized, double-blind crossover study on the use of 5% citrate-lock vs 10% citrate lock.  Blood Purif 23, 101-105, 2005
6.   Vanholder et al, Diagnosis, prevention and treatment of haemodialysis catheter-related blood stream infections (CRBSI), a position statement of European Renal Best Practice (ERBP). NDTplus June 2010
7.   Moran JE and Ash SE, Locking Solutions for Hemodialysis Catheters; Heparin and Citrate.  A Position Paper by ASDIN. Seminars in Dialysis 21,1-3 , 2008